Our Vision

To use neuroscience and engineering advances to improve patient outcomes after neurotrauma

Acute Treatment

We will develop new ways to quickly assess the severity of initial injuries, which will be used to guide acute treatment.

Restoration of function

We will improve long-term clinical outcomes and restore functions by developing new treatments and targeting their use

Prevention

With the Faculty of Engineering we will develop biomechanical and preclinical models of head injury and test novel approaches to brain protection.

Directors

    David Sharp

    / Professor of Neurology

    Dave is an National Institute for Health Research (NIHR) Research Professor and honorary consultant neurologist with a special interest in traumatic brain injury.

    Mark Wilson

    / Consultant Neurosurgeon

    Mark is a Consultant Neurosurgeon and PreHospital Care Specialist working at both Imperial College (mainly St Mary's Major Trauma Centre) and on London's Air Ambulance.

Principal Investigators

    MARTYN BOUTELLE

    / PROFESSOR OF BIOMEDICAL SENSORS ENGINEERING

    Martyn is interested in developing novel microdialysis techniques for measuring fluid in intensive care settings.

    ANTHONY BULL

    / PROFESSOR OF MUSCULOSKELETAL MECHANICS

    Anthony is head of the Department of Bioengineering and is interested in the mechanics of muscles, bones and joints, particularly after blast injury.

    SIMON FLEMINGER

    / CONSULTANT NEUROPSYCHIATRIST

    Simon has over 20 years of experience as a neuropsychiatrist working with adults with acquired brain injury.

    Steven Gentleman

    / Professor of Neuropathology

    Steve is Professor of Neuropathology in the Department of Medicine at Imperial College London. Over the past 20 years he has run an active research team investigating the pathology of neurodegenerative disease and traumatic brain injury.

    Ben Glocker

    / Lecturer in Medical Image Computing

    Ben's research is focused on medical image recognition and automated image analysis. He is developing software tools for quantative imaging including detection and segmentation of brain lesions using machine learning techniques.

    MAZDAK GHAJARI

    / RESEARCH FELLOW

    Mazdak is based in aeronautical engineering and is developing computational models of head injury, which will be used to guide the development of new protective strategies.

    TONY GOLDSTONE

    / CONSULTANT ENDOCRINOLOGIST

    Tony has been a Consultant Endocrinologist at Imperial College Healthcare NHS Trust since 2005, based at the Hammersmith Hospital and St. Mary's Hospital. Tony is interested in the neuroendocrine effects of neurotrauma.

    ADAM HAMPSHIRE

    / NEUROSCIENTIST

    Adam is a neuroscientist with a particular interest in frontal lobe function and also the assessment of cognition after TBI.

    MICHAEL JOHNSON

    / CONSULTANT NEUROLOGIST

    Mike is a neurologist with a special interest in epilepsy. He is currently investigating epilepsy after trauma.

    NARINDER KAPUR

    / CONSULTANT NEUROPSYCHOLOGIST

    Narinder has a Doctorate in Psychology and a Diploma in Clinical Psychology. He has a special interest in memory disorders and the use of memory aids as compensatory strategies for memory rehabilitation.

    ROB LEECH

    / NEUROSCIENTIST

    Rob is a neuroscientist with a particular interest in brain network function.

    ANNE LINGFORD-HUGHES

    / PROFESSOR OF ADDICTION BIOLOGY

    Anne is a psychiatrist interested in how addiction to alcohol/drugs impacts on brain function and how treatment can improve function to help with recovery.

    DANILO MANDIC

    / PROFESSOR OF SIGNAL PROCESSING

    Danilo is interested in developing ultra-wearable, non-invasive ways of measuring biological function after brain injury, and in developing supporting signal processing algorithms.

    PAUL MATTHEWS

    / HEAD OF THE DIVISION OF BRAIN SCIENCES AND PROFESSOR OF CLINICAL NEUROSCIENCE

    Paul is head of the Division of Brain Sciences.

    MANEESH PATEL

    / RADIOLOGY

    Maneesh is a consultant neuroradiologist, with a research interest in neurotrauma.

    VANESSA RAYMONT

    / CONSULTANT PSYCHIATRIST

    Vanessa is a psychiatrist investigating the relationship between alcohol and cognitive outcome after TBI, as well as the chronic psychiatric behavioural sequelae of TBI. She runs the TBI clinical service at West London Mental Health Trust.

    DANIEL RUECKERT

    / PROFESSOR OF VISUAL INFORMATION PROCESSING

    Daniel is very interested in developing different methods of neuroimaging.

    MAGDALENA SASTRE

    / NEUROSCIENTIST

    Magdalena is a basic neuroscientist, investigating the inflammatory and neurodegenerative consequences of TBI and their relationship to neurodegenerative conditions such as dementia.

    BARRY SEEMUNGAL

    / CONSULTANT NEUROLOGIST

    Barry is a consultant neurologist with a specialist interest in dizziness and eye movement problems due to ear, eye and brain disorders including multiple sclerosis, stroke and ataxia. Barry is particularly interested in the acute vestibular effects of neurotrauma.

    STEVE WHITE

    / CONSULTANT NEUROPHYSIOLOGIST

    Steve is a neurophysiologist with a special interest in irritability, aggression and ‘social apraxia’ after TBI, and the presence or absence of post-traumatic epilepsy.

Our Collaborators

The Imperial Neurotrauma Centre team works with numerous groups, both within Imperial College London and external, to try and better understand the mechanisms behind brain and spinal injury and discover new interventions to improve outcomes in our patients. Our multidisciplinary, multidepartmental approach allows us to provide our patients with comprehensive, tailored care.

Our Partners and Funders

Areas of Expertise

Acute Treatment

  • Pre-Hospital Care
  • Invasive Monitoring in Critical Care
  • Vestibular Pathology

Restoration of Function

  • Neuroimaging of TBI
  • Network Dynamics
  • Brain Stimulation
  • Cognitive Testing
  • Epilepsy Prediction
  • Endocrine Dysfunction
  • Neuropathology
  • Neuropsychiatric Problems

Prevention

  • Computational Modelling
  • Helmet Design

Our Publications

Disconnection of Network Hubs Predicts Traumatic Brain Injury and Cognitive Impairment

Prediction of brain age suggests accelerated atrophy in traumatic brain injury

Traumatic brain injury impairs small world connectivity

A robust technique for defining thalamo-cortical connectivity after traumatic brain injury

Default mode network functional and structural connectivity after traumatic brain injury

White matter damage and cognitive impairment after traumatic brain injury

Cognitive flexibility through metastable neural dynamics is disrupted by damage to the structural connectome

Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics

The control of global brain dynamics: opposing actions of fronto-parietal control and default mode networks on attention

Default mode network connectivity predicts sustained attention deficits following traumatic brain injury

Salience network integrity predicts default mode network function after traumatic brain injury.

Damage to the Salience Network impairs its interaction with the Default Mode Network

The neural basis of impaired self-awareness after traumatic brain injury

Individual prediction of white matter injury following traumatic brain injury

Pituitary Dysfunction after Blast Traumatic Brain Injury: UK BIOSAP Study

The neuroinflammatory response in humans after traumatic brain injury

Inflammation after trauma: microglial activation and traumatic brain injury

Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype

Long-term intracerebral inflammatory response after traumatic brain injury.

Trials and tribulations of using APP immunohistochemistry to evaluate traumatic brain injury in adults

Latest News and Events

Little Heros and the C3NL team running a 10k Superheroes Run on Sunday 17th May 2015 for Headway West London

Headway West London is a branch of Headway UK, the national brain injury association charity.

Clinical applications of machine learning in neuroimaging

In August 2015, Dr James Cole from C3NL will be chairing a symposium at the Brain Informatics and Health conference, hosted by Imperial College London and held at the Royal Geographical Society, in South Kensington, London.

The Wonder Street Fair, April 2013

C3NL took part in Wonder: Art and Science on the Brain, a public engagement event

Contact Us

Please get in contact if you would like any further information